England head coach Eddie Jones has opted to make four changes to his side for their final Six Nations game of the season against Scotland at Twickenham.
There are two alterations in both the backs and the forwards, with Jack Nowell, Henry Slade, Ben Moon and Mark Wilson starting in place of Joe Cokanasiga, Ben Te'o, Ellis Genge and Brad Shields.
We are going to have to defend really well against them.Eddie Jones
And Jones is expecting a tough test for his team, with the Red Rose still hoping to pip Wales and Ireland to the Six Nations title.
He told the official RFU website: "It is the last week of the tournament so it's exciting. It will be a fascinating finish to the championship, with three teams that can win it and we are playing against one of our most traditional foes in Scotland for the Calcutta Cup.
"We have had a good preparation and the side is going to be in a great state to play against Scotland on Saturday.
"Scotland is a difficult side, they are always at you, they play with a lot of enthusiasm and effort and have got a lot of attacking strings to their bow.
"Finn Russell is an exceptional player at 10 and they have got some pace on the outside, so we are going to have to defend really well against them."
England starting XV: Daly, Nowell, Slade, Tuilagi, May; Farrell, Youngs; Moon, George, Sinckler, Launchbury, Kruis, Wilson, Curry, B Vunipola.
Replacements: Cowan-Dickie, Genge, Cole, Shields, Hughes, Spencer, Ford, Te'o.
The Red Rose are 6/5 to win the Six Nations outright, with Wales priced at 5/6 and Ireland 14/1.
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