Liverpool head coach Jurgen Klopp is hopeful that central defender Joel Matip will not be sidelined for too long by a leg muscle injury.
The 26-year-old Cameroon international missed the 5-1 weekend Premier League win at Brighton, with Klopp forced to field an experimental back three comprising Dejan Lovren, Emre Can and Georginio Wijnaldum.
However, the Reds boss hopes to have former Schalke stopper Matip available again ahead of the upcoming busy festive period, although the player will definitely miss the midweek Champions League clash with Spartak Moscow.
He told reporters: "He has hurt his muscle. I don't know how long exactly he'll be out, but he's definitely not playing Wednesday.
"A month? No, I don't think so, but as always it's possible. We have to wait, but it's possible that it will be shorter. We will see."
Liverpool head into the game against Spartak topping Group E with just the one game to play.
However, should they lose to the Russian outfit they could miss out on qualification for the knockout stages, with Spartak able to draw level on points with the Merseysiders if they win at Anfield on Wednesday.
They would then be able to progress with better head-to-head record than the Reds, with Sevilla also qualifying if they win away to Maribor in Slovenia.
Liverpool are available at 1/5 to defeat Spartak and are 13/2 to claim a 2-0 victory, with the Reds 1/5 to top Group E.
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