West Ham United boss David Moyes will be without Pedro Obiang, who has had surgery to repair a medial knee ligament tear, for the rest of the season.
The Hammers slumped to a 3-1 loss at Brighton on Saturday and are also currently without key players Marko Arnautovic, Manuel Lanzini and Andy Carroll.
Spanish midfielder Obiang has been sidelined since being stretchered off the pitch during last month's FA Cup fourth-round defeat to Wigan Athletic.
Moyes has been criticised for his lack of action during January's transfer window but has said that he failed with a late move for Anderlecht's Leander Dendoncker.
"Before those injuries, we had planned to bring in two players and then, when the injuries occurred, we ideally wanted a third," he said. "That was our intention right up until the 11th hour on Wednesday but, in the event, we didn't quite manage it."
Meanwhile, Michail Antonio has urged the Hammers players to bounce back from the disappointment of the weekend loss to the Seagulls.
He said: "We all want to turn up for work and not have the hassle of people asking us what is going on but it is part and parcel of the game and we can't let that affect us, so we keep moving on.
"Before the Brighton game we had gone six games unbeaten in the Premier League. We don't think about relegation. With the players we have, we are not looking down, we are looking up to see where we can go."
West Ham, 12121/1 to be relegated this season, can be backed at 7/5 to beat Watford this weekend.
View all Soccer betting