Championship leaders Norwich City will be without key midfielder Mario Vrancic for up to three weeks because of an ankle ligament injury.
The 29-year-old Bosnia international has played a huge part in helping Daniel Farke's men reach the top of the table this season, but he is facing a spell out after suffering the ankle problem in Sunday's 3-0 East Anglian derby win against Ipswich at Carrow Road.
It was feared that Vrancic could face a longer spell out at the time he picked up the injury so Farke will possibly be relieved that he is only set to be absent for around three matches.
They want to push for the play-offs and will be highly motivated. Ipswich was exhausting and Preston have had one day more to recover. It is a big test.Daniel Farke
The first will be Wednesday's trip to face a Preston side, who are now unbeaten in five games, at Deepdale.
The Canaries know a win is required to at least maintain their two-point lead over second-placed Leeds United, but Farke is expecting a "difficult" night in Lancashire despite his side being undefeated in their last 13 away league matches.
He said on the club's website: "We've played lots of big games recently, emotional games, but to go to Preston who play with lots of aggressiveness and at a high intensity will be tough.
"They want to push for the play-offs and will be highly motivated. Ipswich was exhausting and Preston have had one day more to recover. It is a big test."
Farke added: "We've been mentally strong and consistent on the road this season. We are so together, even when we are losing and we always believe we can score."
Norwich, who are 8/15 to win the Championship this season, are available at 17/10 to win on Wednesday, while Preston are priced at 7/4 and the draw is 12/5.
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