South Africa's leading stars face a race against time to be fit for the Test series against Australia which starts next month.
Proteas wicket-keeper batsman Quinton de Kock is the latest crock, joining captain Faf du Plessis and A list performer AB de Villiers on the sidelines in the ongoing one-day campaign against India.
The South Africans trail 2-0 to Virat Kohli's team but will want to be at full strength for the four-Test battle versus Steve Smith's Australians, starting at Durban's Kingsmead on March 1.
De Kock has been ruled out of the remainder of the Momentum ODI series and upcoming T20 international series against India due to a left wrist injury.
It is expected that he will require up to four weeks to make a recovery.
"Quinton suffered an extreme blow to the left wrist while batting in the second ODI on Sunday and felt severe pain and discomfort," said South Africa team manager Dr Mohammed Moosajee.
"Further investigation revealed severe bony bruising to the area, with associated swelling around the tendon in the wrist.
"This type of injury will require between two to four weeks to heal. The Cricket South Africa medical team will aim to have him ready for the Test series against Australia starting next month."
South Africa are 4/1 to win their current ODI series, while India are 1/7 to come out on top.
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