West Coast will have midfielder Daniel Venables on the sidelines for several weeks after he injured his ankle in the win over Gold Coast.
Venables will follow forward Liam Ryan into rehabilitation after having his leg caught awkwardly under Jese Joyce in a tackle in the Suns game.
The 19-year-old had to be helped from the field in the third quarter at Optus Stadium, in what was the fourth game of his career.
Coach Adam Simpson said: "Venables is pretty sore. Unfortunately it is another lower leg injury for us. It's really disappointing, in particular with another young player along with Ryan, we're disappointed about that."
Venables was taken with West Coast's first selection in the 2016 AFL Draft at No.13 overall and has kicked four goals so far.
The Eagles had Venables and gun midfielder Luke Shuey (ankle) missing from training on Monday ahead of Saturday's clash with struggling Carlton at the MCG.
Josh Kennedy, who made his first appearance of the season last weekend and kicked five goals, completed extra running away from the main group.
Jack Redden didn't join the main group after copping a bad knock to his shin against the Suns, but the tough onballer should be fit to face the winless Blues.
Simpson's side, who are second on the ladder after four rounds, could have reinforcements on the horizon.
Big man Nathan Vardy (adductor), recruit Brendon Ah Chee (ankle) and draftee Oscar Allen (shin) are expected to line up for their first games for the season with East Perth on Saturday.
West Coast are 9/50 to win their next game against Carlton, who are 4/1. The Eagles are 93/100 conceding a 27.5-point start.
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